The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility ...

A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects. Protein complexes that adorn the surface of T cells ...

Expression of co-inhibitory receptors or “checkpoint” molecules, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of ...

In a recent article published in the Science Immunology Journal, researchers probed for antibody binding against all seven human coronaviruses (hCoVs) and 49 animal coronaviruses (aCoVs) represented ...

Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family ...

Please provide your email address to receive an email when new articles are posted on . Eleven patients reported 22 reactions during intradermal testing. Nine of 11 patients displayed cross-reactivity ...

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Cells ...

Opioid cross-reactivity is the uncommon occurrence of having an allergic reaction to more than one opioid. Allergies to opioids present a unique challenge in pain management due to the limited ...

Breaking a longstanding impasse in our understanding of olfaction, scientists at UC San Francisco have created the first molecular-level, 3D picture of how an odor molecule activates a human odorant ...