The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility ...

A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects. Protein complexes that adorn the surface of T cells ...

In a recent article published in the Science Immunology Journal, researchers probed for antibody binding against all seven human coronaviruses (hCoVs) and 49 animal coronaviruses (aCoVs) represented ...

Expression of co-inhibitory receptors or “checkpoint” molecules, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of ...

Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family ...

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Cells ...

Please provide your email address to receive an email when new articles are posted on . Eleven patients reported 22 reactions during intradermal testing. Nine of 11 patients displayed cross-reactivity ...

Opioid cross-reactivity is the uncommon occurrence of having an allergic reaction to more than one opioid. Allergies to opioids present a unique challenge in pain management due to the limited ...