Infographic: Designing Transition-State Inhibitors View full size JPG | PDF LUCY READING-IKKANDA A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any ...

Using computational design and directed evolution, scientists have successfully created a metalloprotein that can catalyze a commonly used organic reaction more efficiently than any known enzyme (Nat.

AMES, Iowa – Peter Reilly pointed to the framed journal covers decorating his office. Each of the six showed the swirling, twisting, complicated structure of an enzyme. Those bright and colorful ...

Directed evolution—a process in which a protein library is subjected to repeated rounds of mutation and selection to achieve desired properties—can improve the catalytic performance of computationally ...

Researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...