Infographic: Designing Transition-State Inhibitors View full size JPG | PDF LUCY READING-IKKANDA A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any ...

Using computational design and directed evolution, scientists have successfully created a metalloprotein that can catalyze a commonly used organic reaction more efficiently than any known enzyme (Nat.

AMES, Iowa – Peter Reilly pointed to the framed journal covers decorating his office. Each of the six showed the swirling, twisting, complicated structure of an enzyme. Those bright and colorful ...

Researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

Directed evolution—a process in which a protein library is subjected to repeated rounds of mutation and selection to achieve desired properties—can improve the catalytic performance of computationally ...

The enzymes found in living organisms have impressive catalytic power. Thanks to enzymes, the chemical reactions that sustain life happen millions of times faster than they would occur without them.

Advances in cloud computing and artificial intelligence are driving breakthroughs for researchers in the fields of life sciences, biotech, and drug discovery. Enabled by artificial intelligence and ...