The 49ers definitely will be without defensive tackle Kevin Givens (groin), punter Mitch Wishnowsky (back) and cornerback Charvarius Ward (personal), all of whom got an “out” designation Friday. Ward has not rejoined the team following the loss of his 1-year-old daughter last month.

San Francisco 49ers head coach Kyle Shanahan on Wednesday had some good news regarding tight end George Kittle. Kittle injured his hamstring during the 49ers' Week 10 win over the Tampa Bay Buccaneers.

The 49ers have some injury concerns ahead of Sunday's game against the Seahawks. Left tackle Trent Williams (ankle), defensive end Nick Bosa (hip) and tight end George Kittle (hamstring) are questionable.

Earlier this season, San Francisco 49ers tight end George Kittle wore an Iowa State helmet while speaking to reporters after losing a bet to quarterback

Two 49ers stars are questionable for San Francisco's NFC West showdown against the Seattle Seahawks on Sunday at Levi's Stadium.

George Kittle lived up to expectations on Thursday as he returned to practice for the San Francisco 49ers ahead of their Week 11 matchup with the Seattle Seahawks. But the boost the All-Pro tight end provided after missing Wednesday's practice with hamstring irritation was cancelled out somewhat by concerning news surrounding another of San Francisco's playmakers.

As the San Francisco 49ers prepare for their Week 11 battle with the Seattle Seahawks, the Niners appear to be getting one of their offensive stars back on the field this week, as George Kittle returned to practice on Thursday following a minor hamstring injury.