gut.bmj

Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression

Correspondence to Dr Chun-Ming Wong, State Key Laboratory of Liver Research and Department of Pathology, University of Hong Kong Li Ka Shing, Hong Kong, Hong Kong; jackwong{at}pathology.hku.hk; Dr ...
Gut

Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis

Background Chronic pancreatitis (CP) is a risk factor for pancreatic cancer, with inherited cases conferring a markedly increased risk. The underlying mechanisms driving malignant transformation by CP ...
Gut

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

Background Western diet and associated production of secondary bile acids (BAs) have been linked to the development of ...
Gut

Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women

Background Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut–brain axis. Objective The objective of this study was to ...
Gut

Response to ‘Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data’

We read with great interest the study by Van der Voort et al ,1 which compared rectal versus colonic submucosal cancer rates ...
GutOpinion

Red cells, red flags: are we harming stable patients with outdated transfusion thresholds?

The 2022 UK-wide acute upper gastrointestinal bleeding (AUGIB) audit by Nigam and colleagues is a landmark. With ...
gut.bmj

Pharmacological trials of early intervention in predicted severe acute pancreatitis: implications for therapeutic window and core outcome set

We read with great interest the recent randomised trial by Huang et al evaluating cyclooxygenase-2 inhibitors (COX-2-Is) in predicted severe acute pancreatitis (AP).1 Although no dose-response of ...
gut.bmj

Does a long time to colonoscopy after a positive faecal immunochemical test result have a deleterious impact on colorectal cancer outcomes? A nationwide cohort study

Background Depending on the colorectal cancer (CRC) screening programme, a colonoscopy should be performed within 1–3 months after a positive faecal immunochemical test (FIT) result. However, such ...
gut.bmj

Number of reflux episodes on pH-impedance monitoring associates with improved symptom outcome and treatment satisfaction in gastro-oesophageal reflux disease (GERD) patients ...

Objective Number of reflux episodes, an adjunctive metric on pH-impedance monitoring, is incompletely studied. We aimed to determine if number of reflux episodes associates with therapeutic outcome in ...
gut.bmj

High-protein diets alleviate tumour growth and drug resistance by promoting AKT aggregation and turnover

Background Despite the long-standing recommendations of high-protein diets for patients with cancer, the precise mechanisms of this dietary approach in benefiting tumour suppression and enhancing ...
gut.bmj

The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)

Correspondence to Dr Silvio Danese, Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Lombardia, Italy; ...
gut.bmj

Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles

a Department of Molecular and Cellular Pathology, University of Dundee, Dundee, UK, b School of Applied Science, South Bank University, London, UK Dr M J Hopkins, MRC Microbiology and Gut Biology ...